Quote Now
Lab Animal Equipment
Lab Animal Equipment
Home » Product » Startle Reflex System
  • Startle Reflex System
  • Startle Reflex System
  • Startle Reflex System
  • Startle Reflex System
  • Startle Reflex System
  • Startle Reflex System

Startle Reflex System

Prepulse inhibition (PPI) is the phenomenon in which a weak prepulse stimulus attenuates the response to a subsequent startling stimulus. The stimuli are usually acoustic, light and tactile stimuli. Patients with schizophrenia and some other neuropsychiatric disorders have impaired PPI.Science’s Rodent Startle Reflex System allows for Pre-pulse inhibition and fear-potentiated startle protocols efficiently and economically. Animal models are widely used to test hopotheses linking genetic components of various diseases.

Get A Quote
Product
Overview Specification Reference How to Order
Overview

Prepulse inhibition (PPI) is the phenomenon in which a weak prepulse stimulus attenuates the response to a subsequent startling stimulus. The stimuli are usually acoustic, light and tactile stimuli. Patients with schizophrenia and some other neuropsychiatric disorders have impaired PPI.Science’s Rodent Startle Reflex System allows for Pre-pulse inhibition and fear-potentiated startle protocols efficiently and economically. Animal models are widely used to test hopotheses linking genetic components of various diseases.

Features

  • Applicable for Rats and Mice, maximum 16 chambers.
  • Adopts user-friendly graphical interface settings, experiment building and modification can be achieved by clicking the icon or picture directly.
  • Sound, light, electricity and tactile stimuli occur simultaneously or in serial, and can be freely combined. Available for Habituation, Pre-pulse Inhibition(PPI), Potentiated Startle or user-defined experiments.
Specification

General

  • Applicable for Rats and Mice, maximum 16 chambers.
  • Adopts user-friendly graphical interface settings, experiment building and modification can be achieved by clicking the icon or picture directly.
  • Sound, light, electricity and tactile stimuli occur simultaneously or in serial, and can be freely combined.
  • Available for Habituation, Pre-pulse Inhibition (PPI), Potentiated Startle or user-defined experiments.

Pinciple

  • The high-precision three-axis digital sensor can detect the muscle contraction response of animals in any direction of XYZ, effectively solving the problem of animals in one direction and electromagnetic interference.
  • 16bit resolution, accuracy up to 1/65536
  • Sensor supports calibration
  • Special algorithms are used to remove the effect of sound itself on the sensor.

Sound

  • Speaker: Raise and lower volume based on intrachamber volume (from the detector).
  • AI detection, real time sound intensity display.
  • White Noise Generator included in default Software, include White Noise and Tone.
  • White noise stimulus: duration 1～6000ms, Max 130db.
  • Tone stimulus: duration time 1 ～ 6000ms, frequency range 100~20000Hz, Max 130db.
    intensity can be set by software.

Shock Grid

  • 0.1-4.0mA in 0.1mA steps.
  • AC Current. Alternating pulse current ensure fully shock.
  • Removable Grid.
  • Frequency: 1000Hz, 1ms per time.
  • Full digital control, scramble-frequency constant electrical stimulator makes it no rule in animal side.

Tactile stimulation

  • The intensity of stimulation can be adjusted by adjusting the pressure of the compressed gas cylinder.

Software

Data Recording

  • PPI Result
    • Decibel
    • ASRp (PP+ST amplitude)
    • ASRC (ST amplitude)
    • PPI Pct (PPI inhibition rate)
  • Trial results
    • Db (sound) Peak Value, Total Value, ASR standard deviation)
    • Rms Value (root mean square) Start (start time) End (end time) Period Cnt (duration)
  • PPI Cal Details: detailed amplitude data under the corresponding decibel sound (including the corresponding Block and Trial numbers)
  • PPI Pct
    • Calculation formula and results of ASRp, calculation formula and results of ASRc, calculation formula of PPI (ASRC-ASRP) /ASRc and results of suppression ratio for appropriate decibel sound
    • Table of 1000 time-amplitude correspondence data in 1s

Size

  • Main Controller: 22 x 11 x 32cm (width x depth x height).
  • Secondary Controller: 28 x 7 x 21cm (width x depth x height).
  • Restrainer: mouse 6cm*6*10cm, rat 10.5cm*10.5cm*15cm (width x depth x height).
  • Sound attenuation cubicle: 46 x 60 x 44 cm (width x depth x height).
  • Sound attenuation cubicle is equipped with fan which can be start and stopped by software.
Reference

Reference

Prepulse Inhibition (PPI) is a well-established paradigm widely cited in neuropsychiatric research, particularly in studies on schizophrenia, sensorimotor gating, and genetic models of brain disorders. The PPI test is frequently used to validate animal models and explore the neurological basis of psychiatric conditions, making it a valuable tool in translational neuroscience.

How to Order

Ordering Information

Item No. Product
SA217-R Startle Reflex System for Rat
SA217-M Startle Reflex System for Mouse

Start Now

Quality First, Cost Effective, Reputation Above All.

form-background

    Message *

    Related Products